HIF-1α stimulates aromatase expression driven by prostaglandin E(2 )in breast adipose stroma

INTRODUCTION: The majority of postmenopausal breast cancers are estrogen-dependent. Tumor-derived factors, such as prostaglandin E(2 )(PGE(2)), stimulate CREB1 binding to cAMP response elements (CREs) on aromatase promoter II (PII), leading to the increased expression of aromatase and biosynthesis o...

Descripción completa

Detalles Bibliográficos
Autores principales: Samarajeewa, Nirukshi U, Yang, Fangyuan, Docanto, Maria M, Sakurai, Minako, McNamara, Keely M, Sasano, Hironobu, Fox, Stephen B, Simpson, Evan R, Brown, Kristy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672802/
https://www.ncbi.nlm.nih.gov/pubmed/23566437
http://dx.doi.org/10.1186/bcr3410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672802/
https://www.ncbi.nlm.nih.gov/pubmed/23566437
http://dx.doi.org/10.1186/bcr3410

Ejemplares similares