Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation

T lymphocytes regulate nutrient uptake to meet the metabolic demands of immune activation. The present study shows that the intracellular supply of large neutral amino acids (LNAAs) in T cells is regulated by pathogen and the T cell antigen receptor (TCR). A single System L transporter, Slc7a5, medi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sinclair, Linda V., Rolf, Julia, Emslie, Elizabeth, Shi, Yun-Bo, Taylor, Peter M., Cantrell, Doreen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672957/
https://www.ncbi.nlm.nih.gov/pubmed/23525088
http://dx.doi.org/10.1038/ni.2556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672957/
https://www.ncbi.nlm.nih.gov/pubmed/23525088
http://dx.doi.org/10.1038/ni.2556

Ejemplares similares