The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism

DDC (diethyldithiocarbamate) could block collagen synthesis in HSC (hepatic stellate cells) through the inhibition of ROS (reactive oxygen species) derived from hepatocyte CYP2E1 (cytochrome P450 2E1). However, the effect of DDC on MMP-1 (matrix metalloproteinase-1), which is the main collagen degra...

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Detalles Bibliográficos
Autores principales: Liu, Tianhui, Wang, Ping, Cong, Min, Xu, Youqing, Jia, Jidong, You, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673035/
https://www.ncbi.nlm.nih.gov/pubmed/23577625
http://dx.doi.org/10.1042/BSR20130033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673035/
https://www.ncbi.nlm.nih.gov/pubmed/23577625
http://dx.doi.org/10.1042/BSR20130033

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