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Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles

The Eph (erythropoietin-producing hepatocellular carcinoma) B receptors are important in a variety of cellular processes through their roles in cell-to-cell contact and signalling; their up-regulation and down-regulation has been shown to have implications in a variety of cancers. A greater understa...

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Detalles Bibliográficos
Autores principales: Overman, Ross C., Debreczeni, Judit E., Truman, Caroline M., McAlister, Mark S., Attwood, Teresa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673036/
https://www.ncbi.nlm.nih.gov/pubmed/23627399
http://dx.doi.org/10.1042/BSR20130028