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Predicting the functional consequences of cancer-associated amino acid substitutions

Motivation: The number of missense mutations being identified in cancer genomes has greatly increased as a consequence of technological advances and the reduced cost of whole-genome/whole-exome sequencing methods. However, a high proportion of the amino acid substitutions detected in cancer genomes...

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Detalles Bibliográficos
Autores principales: Shihab, Hashem A., Gough, Julian, Cooper, David N., Day, Ian N. M., Gaunt, Tom R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673218/
https://www.ncbi.nlm.nih.gov/pubmed/23620363
http://dx.doi.org/10.1093/bioinformatics/btt182