A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number

Motivation: cis-regulatory DNA sequence elements, such as enhancers and silencers, function to control the spatial and temporal expression of their target genes. Although the overall levels of gene expression in large cell populations seem to be precisely controlled, transcription of individual gene...

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Detalles Bibliográficos
Autores principales: Woodcock, Dan J., Vance, Keith W., Komorowski, Michał, Koentges, Georgy, Finkenstädt, Bärbel, Rand, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673223/
https://www.ncbi.nlm.nih.gov/pubmed/23677939
http://dx.doi.org/10.1093/bioinformatics/btt201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673223/
https://www.ncbi.nlm.nih.gov/pubmed/23677939
http://dx.doi.org/10.1093/bioinformatics/btt201

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