Functional Recurrent Mutations in the Human Mitochondrial Phylogeny: Dual Roles in Evolution and Disease

Mutations frequently reoccur in the human mitochondrial DNA (mtDNA). However, it is unclear whether recurrent mtDNA nodal mutations (RNMs), that is, recurrent mutations in stems of unrelated phylogenetic nodes, are functional and hence selectively constrained. To answer this question, we performed c...

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Detalles Bibliográficos
Autores principales: Levin, Liron, Zhidkov, Ilia, Gurman, Yotam, Hawlena, Hadas, Mishmar, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673625/
https://www.ncbi.nlm.nih.gov/pubmed/23563965
http://dx.doi.org/10.1093/gbe/evt058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673625/
https://www.ncbi.nlm.nih.gov/pubmed/23563965
http://dx.doi.org/10.1093/gbe/evt058

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