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A Genomic Survey of HECT Ubiquitin Ligases in Eukaryotes Reveals Independent Expansions of the HECT System in Several Lineages

The posttranslational modification of proteins by the ubiquitination pathway is an important regulatory mechanism in eukaryotes. To date, however, studies on the evolutionary history of the proteins involved in this pathway have been restricted to E1 and E2 enzymes, whereas E3 studies have been focu...

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Detalles Bibliográficos
Autores principales: Grau-Bové, Xavier, Sebé-Pedrós, Arnau, Ruiz-Trillo, Iñaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673628/
https://www.ncbi.nlm.nih.gov/pubmed/23563970
http://dx.doi.org/10.1093/gbe/evt052