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X-ray irradiation promotes apoptosis of hippocampal neurons through up-regulation of Cdk5 and p25
BACKGROUND: Cranial radiation therapy has been used for the treatment of primary and metastatic brain tumors. A prominent feature of brain injury induced by the radiation therapy is hippocampal dysfunction, characterized by a decline in memory. Cdk5 plays an important role in memory formation. Abnor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673899/ https://www.ncbi.nlm.nih.gov/pubmed/23688022 http://dx.doi.org/10.1186/1475-2867-13-47 |