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Granulin Exacerbates Lupus Nephritis via Enhancing Macrophage M2b Polarization

BACKGROUND AND AIMS: Lupus nephritis (LN), with considerable morbidity and mortality, is one of the most severe manifestations of systemic lupus erythematosus (SLE). Yet, the pathogenic mechanisms of LN have not been clearly elucidated, and efficient therapies are still in great need. Granulin (GRN)...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Wen, Zhenke, Xu, Wei, Xiong, Sidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673914/
https://www.ncbi.nlm.nih.gov/pubmed/23755248
http://dx.doi.org/10.1371/journal.pone.0065542