Identification of Subunit-Subunit Interaction Sites in αA-WT Crystallin and Mutant αA-G98R Crystallin Using Isotope-Labeled Cross-Linker and Mass Spectrometry

Cataract is characterized by progressive protein aggregation and loss of vision. α-Crystallins are the major proteins in the lens responsible for maintaining transparency. They exist in the lens as highly polydisperse oligomers with variable numbers of subunits, and mutations in α-crystallin are ass...

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Detalles Bibliográficos
Autores principales: Kannan, Rama, Santhoshkumar, Puttur, Mooney, Brian P., Sharma, K. Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673982/
https://www.ncbi.nlm.nih.gov/pubmed/23755258
http://dx.doi.org/10.1371/journal.pone.0065610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673982/
https://www.ncbi.nlm.nih.gov/pubmed/23755258
http://dx.doi.org/10.1371/journal.pone.0065610

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