Cargando…

Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer

Here, we interrogated head and neck cancer (HNSCC) specimens (n = 12) to examine if different metabolic compartments (oxidative vs. glycolytic) co-exist in human tumors. A large panel of well-established biomarkers was employed to determine the metabolic state of proliferative cancer cells. Interest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Curry, Joseph M., Tuluc, Madalina, Whitaker-Menezes, Diana, Ames, Julie A., Anantharaman, Archana, Butera, Aileen, Leiby, Benjamin, Cognetti, David M., Sotgia, Federica, Lisanti, Michael P., Martinez-Outschoorn, Ubaldo E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674065/ https://www.ncbi.nlm.nih.gov/pubmed/23574725 http://dx.doi.org/10.4161/cc.24092

Ejemplares similares

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4
por: Martinez-Outschoorn, Ubaldo E, et al.
Publicado: (2013)

Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer
por: Bisetto, Sara, et al.
Publicado: (2018)

MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer
por: Johnson, Jennifer M., et al.
Publicado: (2017)

Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis
por: Bovenzi, Cory D., et al.
Publicado: (2015)

Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis
por: Sheng, Gaohong, et al.
Publicado: (2023)

MCT1 regulates aggressive and metabolic phenotypes in bladder cancer
por: Zhang, Guiming, et al.
Publicado: (2018)

Thyroid Cancer Metabolism: A Review
por: Gill, Kurren S, et al.
Publicado: (2016)

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition
por: Lamb, Rebecca, et al.
Publicado: (2014)

Cancer Metabolism: New Validated Targets for Drug Discovery
por: Sotgia, Federica, et al.
Publicado: (2013)

MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism
por: Petersen, Charlotte, et al.
Publicado: (2017)

Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10
por: Porst, Theresa, et al.
Publicado: (2021)

Inhibition of Hypothalamic MCT4 and MCT1–MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions
por: Elizondo-Vega, Roberto, et al.
Publicado: (2019)

Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells
por: Kershaw, Stephen, et al.
Publicado: (2015)

Cancer stem cell metabolism
por: Peiris-Pagès, Maria, et al.
Publicado: (2016)

MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG
por: Fets, Louise, et al.
Publicado: (2018)

Preclinical Incorporation Dosimetry of [(18)F]FACH—A Novel (18)F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET
por: Sattler, Bernhard, et al.
Publicado: (2020)

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells
por: Benjamin, Don, et al.
Publicado: (2018)

Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4
por: Rademakers, Saskia E, et al.
Publicado: (2011)

Insights Into the Mechanism of MCT8 Oligomerization
por: Groeneweg, Stefan, et al.
Publicado: (2020)

Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification
por: Buyse, Chloe, et al.
Publicado: (2022)

Tissue expression of lactate transporters (MCT1 and MCT4) and prognosis of malignant pleural mesothelioma (brief report)
por: Dell’Anno, Irene, et al.
Publicado: (2020)

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells
por: Salem, Ahmed F., et al.
Publicado: (2012)

High expression of monocarboxylate transporter 4 (MCT 4), but not MCT 1, predicts poor prognosis in patients with non-small cell lung cancer
por: Tong, Ying-Hui, et al.
Publicado: (2021)

Critical Velocity, Maximal Lactate Steady State, and Muscle MCT1 and MCT4 after Exhaustive Running in Mice
por: Orsi, Juan B., et al.
Publicado: (2023)

Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial
por: Curry, Joseph, et al.
Publicado: (2017)

MCT Expression and Lactate Influx/Efflux in Tanycytes Involved in Glia-Neuron Metabolic Interaction
por: Cortés-Campos, Christian, et al.
Publicado: (2011)

Evaluation of MCT1, MCT4 and CD147 Genes in Peripheral Blood Cells of Breast Cancer Patients and Their Potential Use as Diagnostic and Prognostic Markers
por: Luz, Maria Cláudia de B., et al.
Publicado: (2017)

Marked Seizure Reduction after MCT Supplementation
por: Azzam, Raed, et al.
Publicado: (2013)

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor Microenvironment
por: Liu, Tian, et al.
Publicado: (2023)

Hyperoxia induces glucose metabolism reprogramming and intracellular acidification by suppressing MYC/MCT1 axis in lung cancer
por: Liu, Xiucheng, et al.
Publicado: (2023)

Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer
por: Valença, Isabel, et al.
Publicado: (2015)

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth
por: Capparelli, Claudia, et al.
Publicado: (2012)

Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers
por: Domingo-Vidal, Marina, et al.
Publicado: (2022)

Intranasal delivery of Thyroid hormones in MCT8 deficiency
por: Grijota-Martínez, Carmen, et al.
Publicado: (2020)

Monocarboxylate Transporter 1 (MCT1) in Liver Pathology
por: Droździk, Marek, et al.
Publicado: (2020)

Metacognitive training for psychosis (MCT): past, present, and future
por: Moritz, Steffen, et al.
Publicado: (2022)

Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells
por: Saulle, Ernestina, et al.
Publicado: (2021)

CRISPR/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat
por: Bae, Hee Sook, et al.
Publicado: (2020)

Metformin Clinical Trial in HPV+ and HPV– Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate
por: Curry, Joseph M., et al.
Publicado: (2018)

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer
por: Latif, Ayşe, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0hoffioqstnvgu5rtaqdi99pol