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Pre-mRNA processing factors meet the DNA damage response

It is well-known that DNA-damaging agents induce genome instability, but only recently have we begun to appreciate that chromosomes are fragile per se and frequently subject to DNA breakage. DNA replication further magnifies such fragility, because it leads to accumulation of single-stranded DNA. Re...

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Detalles Bibliográficos
Autores principales: Montecucco, Alessandra, Biamonti, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674313/
https://www.ncbi.nlm.nih.gov/pubmed/23761808
http://dx.doi.org/10.3389/fgene.2013.00102