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FoxO3a is activated and executes neuron death via Bim in response to β-amyloid
The molecules that mediate death of selective neurons in Alzheimer's disease (AD) are mostly unknown. The Forkhead transcription factor FoxO3a has emerged as an important mediator of cell fate including apoptosis. When phosphorylated by Akt, it is localized in the cytosol as an inactive complex...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674357/ https://www.ncbi.nlm.nih.gov/pubmed/23661003 http://dx.doi.org/10.1038/cddis.2013.148 |