Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

Cancer cells may survive under oxygen and nutrient deprivation by metabolic reprogramming for high levels of anaerobic glycolysis, which contributes to tumor growth and drug resistance. Abnormally expressed glucose transporters (GLUTs) are colocalized with hypoxia (Hx) inducible factor (HIF)1α in pe...

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Detalles Bibliográficos
Autores principales: Huang, C-Y, Kuo, W-T, Huang, Y-C, Lee, T-C, Yu, L C H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674358/
https://www.ncbi.nlm.nih.gov/pubmed/23640464
http://dx.doi.org/10.1038/cddis.2013.149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674358/
https://www.ncbi.nlm.nih.gov/pubmed/23640464
http://dx.doi.org/10.1038/cddis.2013.149

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