Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity

Acute hepatic failure secondary to acetaminophen (APAP) poisoning is associated with high mortality. Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of tyrosine kinase growth factor signaling. In the liver, this pathway confers protection against injury. However, the involvement of P...

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Detalles Bibliográficos
Autores principales: Mobasher, M A, González-Rodriguez, Á, Santamaría, B, Ramos, S, Martín, M Á, Goya, L, Rada, P, Letzig, L, James, L P, Cuadrado, A, Martín-Pérez, J, Simpson, K J, Muntané, J, Valverde, A M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674359/
https://www.ncbi.nlm.nih.gov/pubmed/23661004
http://dx.doi.org/10.1038/cddis.2013.150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674359/
https://www.ncbi.nlm.nih.gov/pubmed/23661004
http://dx.doi.org/10.1038/cddis.2013.150

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