SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells

We explored the activity of SIRT1 activators (SRT501 and SRT2183) alone and in combination with panobinostat in a panel of malignant lymphoid cell lines in terms of biological and gene expression responses. SRT501 and SRT2183 induced growth arrest and apoptosis, concomitant with deacetylation of STA...

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Detalles Bibliográficos
Autores principales: Scuto, A, Kirschbaum, M, Buettner, R, Kujawski, M, Cermak, J M, Atadja, P, Jove, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674366/
https://www.ncbi.nlm.nih.gov/pubmed/23681230
http://dx.doi.org/10.1038/cddis.2013.159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674366/
https://www.ncbi.nlm.nih.gov/pubmed/23681230
http://dx.doi.org/10.1038/cddis.2013.159

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