Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway

Alterations in mitochondria and increased oxidative stress are associated with the disease progression in Huntington's disease (HD). Endoplasmic reticulum (ER) stress and oxidative damage are linked through the close communication between the ER and mitochondria. Sigma-1 receptor (Sig-1R) is a...

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Detalles Bibliográficos
Autores principales: Hyrskyluoto, A, Pulli, I, Törnqvist, K, Huu Ho, T, Korhonen, L, Lindholm, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674377/
https://www.ncbi.nlm.nih.gov/pubmed/23703391
http://dx.doi.org/10.1038/cddis.2013.170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674377/
https://www.ncbi.nlm.nih.gov/pubmed/23703391
http://dx.doi.org/10.1038/cddis.2013.170

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