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Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway
Alterations in mitochondria and increased oxidative stress are associated with the disease progression in Huntington's disease (HD). Endoplasmic reticulum (ER) stress and oxidative damage are linked through the close communication between the ER and mitochondria. Sigma-1 receptor (Sig-1R) is a...
Autores principales: | Hyrskyluoto, A, Pulli, I, Törnqvist, K, Huu Ho, T, Korhonen, L, Lindholm, D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674377/ https://www.ncbi.nlm.nih.gov/pubmed/23703391 http://dx.doi.org/10.1038/cddis.2013.170 |
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