Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP

Rab GTPases are emerging targets of diverse bacterial pathogens. Here, we perform biochemical and structural analyses of LepB, a Rab GTPase-activating protein (GAP) effector from Legionella pneumophila. We map LepB GAP domain to residues 313-618 and show that the GAP domain is Rab1 specific with a c...

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Detalles Bibliográficos
Autores principales: Yu, Qin, Hu, Liyan, Yao, Qing, Zhu, Yongqun, Dong, Na, Wang, Da-Cheng, Shao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674391/
https://www.ncbi.nlm.nih.gov/pubmed/23588383
http://dx.doi.org/10.1038/cr.2013.54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674391/
https://www.ncbi.nlm.nih.gov/pubmed/23588383
http://dx.doi.org/10.1038/cr.2013.54

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