Identification of a small molecule 1,4-bis-[4-(3-phenoxy-propoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53

AIM: To identify novel small compound inhibitor of p53 protein. METHODS: Mouse embryonic fibroblasts (MEF) and mouse embryonic stem (ES) cells were tested. Cell proliferation rate was determined using a Cell Proliferation Kit. The mRNA and protein levels of p53-related genes were measured using real...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Zhang, Ying, Tong, Man, Liu, Xiu-ying, Luo, Guan-zheng, Xie, Dong-fang, Ren, Shao-fang, Bai, Dong-hui, Wang, Liu, Zhou, Qi, Wang, Xiu-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674519/
https://www.ncbi.nlm.nih.gov/pubmed/23736005
http://dx.doi.org/10.1038/aps.2013.61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674519/
https://www.ncbi.nlm.nih.gov/pubmed/23736005
http://dx.doi.org/10.1038/aps.2013.61

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