Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners

Polyglutamine (polyQ) diseases are genetically inherited neurodegenerative disorders. They are caused by mutations that result in polyQ expansions of particular proteins. Mutant proteins form intranuclear aggregates, induce cytotoxicity and cause neuronal cell death. Protein interaction data suggest...

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Detalles Bibliográficos
Autores principales: Petrakis, Spyros, Schaefer, Martin H, Wanker, Erich E, Andrade-Navarro, Miguel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Insights & Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674527/
https://www.ncbi.nlm.nih.gov/pubmed/23483542
http://dx.doi.org/10.1002/bies.201300001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674527/
https://www.ncbi.nlm.nih.gov/pubmed/23483542
http://dx.doi.org/10.1002/bies.201300001

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