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Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors

INTRODUCTION: Ankylosing spondylitis (AS) is unique in its pathology where inflammation commences at the entheses before progressing to an osteoproliferative phenotype generating excessive bone formation that can result in joint fusion. The underlying mechanisms of this progression are poorly unders...

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Detalles Bibliográficos
Autores principales: Haynes, Katelin R, Pettit, Allison R, Duan, Ran, Tseng, Hsu-Wen, Glant, Tibor T, Brown, Matthew A, Thomas, Gethin P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674607/
https://www.ncbi.nlm.nih.gov/pubmed/23171658
http://dx.doi.org/10.1186/ar4096