Dose-Dependent Targeted Suppression of P-glycoprotein Expression and Function in Caco-2 Cells

[Image: see text] The efflux transporter P-glycoprotein (Pgp), encoded by the ABCB1 gene, decreases the bioavailability of a wide range of orally administered drugs. Drug permeability studies using the in vitro Caco-2 cell model commonly rely on small molecule modulators to estimate the contribution...

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Detalles Bibliográficos
Autores principales: Lee, Stephen D., Osei-Twum, Jo-Ann, Wasan, Kishor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674641/
https://www.ncbi.nlm.nih.gov/pubmed/23611024
http://dx.doi.org/10.1021/mp300668e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674641/
https://www.ncbi.nlm.nih.gov/pubmed/23611024
http://dx.doi.org/10.1021/mp300668e

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