Cargando…

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2

Regulatory T (T reg) cells control progression to autoimmune diabetes in the BDC2.5/NOD mouse model by reining in natural killer (NK) cells that infiltrate the pancreatic islets, inhibiting both their proliferation and production of diabetogenic interferon-γ. In this study, we have explored the mole...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sitrin, Jonathan, Ring, Aaron, Garcia, K. Christopher, Benoist, Christophe, Mathis, Diane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674700/ https://www.ncbi.nlm.nih.gov/pubmed/23650440 http://dx.doi.org/10.1084/jem.20122248

Ejemplares similares

CD4(+)CD25(+) T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion
por: Herman, Ann E., et al.
Publicado: (2004)

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
por: Coppieters, Ken T., et al.
Publicado: (2012)

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33
por: Tuncel, Jonatan, et al.
Publicado: (2019)

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
por: Wong, Jamie, et al.
Publicado: (2007)

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints
por: Nishio, Junko, et al.
Publicado: (2010)

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
por: Zemmour, David, et al.
Publicado: (2018)

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?
por: Benoist, Christophe, et al.
Publicado: (2000)

Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk
por: Wu, Hsin-Jung, et al.
Publicado: (2007)

CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance
por: Michelson, Daniel A., et al.
Publicado: (2022)

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities
por: Lühder, Fred, et al.
Publicado: (1998)

IL-10(+) NK and TGF-β(+) NK cells play negative regulatory roles in HIV infection
por: Jiang, Yongjun, et al.
Publicado: (2018)

The AKT–mTOR axis regulates de novo differentiation of CD4(+)Foxp3(+) cells
por: Haxhinasto, Sokol, et al.
Publicado: (2008)

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells
por: van Santen, Hisse-Martien, et al.
Publicado: (2004)

Developmental and cellular age direct conversion of CD4(+) T cells into RORγ(+) or Helios(+) colon Treg cells
por: Pratama, Alvin, et al.
Publicado: (2019)

IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner
por: Mann, Alexander O., et al.
Publicado: (2022)

IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
por: Gasteiger, Georg, et al.
Publicado: (2013)

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
por: Gray, Daniel, et al.
Publicado: (2007)

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model
por: Turley, Shannon, et al.
Publicado: (2003)

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
por: Obst, Reinhard, et al.
Publicado: (2005)

Visualization of CD4/CD8 T Cell Commitment
por: Chan, Susan, et al.
Publicado: (1998)

NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype
por: Marcon, Francesca, et al.
Publicado: (2020)

Regulatory NK cells in autoimmune disease
por: Bahadorian, Davood, et al.
Publicado: (2023)

Where CD4(+)CD25(+) T reg cells impinge on autoimmune diabetes
por: Chen, Zhibin, et al.
Publicado: (2005)

A multiple redundant genetic switch locks in the transcriptional signature of T regulatory cells
por: Fu, Wenxian, et al.
Publicado: (2012)

Development and function of murine B220(+)CD11c(+)NK1.1(+) cells identify them as a subset of NK cells
por: Blasius, Amanda L., et al.
Publicado: (2007)

IL-2 analogues: novel agents circumventing the expansion of T regulatory cells while promoting NK cell activation during IL-2 therapy
por: Sim, Geok Choo, et al.
Publicado: (2013)

Exogenous activated NK cells enhance trafficking of endogenous NK cells to endometriotic lesions
por: Montenegro, Mary Lourdes, et al.
Publicado: (2015)

Regulatory effects of dexamethasone on NK and T cell immunity
por: Chen, Liying, et al.
Publicado: (2017)

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes
por: Höglund, Petter, et al.
Publicado: (1999)

Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation
por: Phillips, Brett E., et al.
Publicado: (2021)

NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface
por: Blois, Sandra M., et al.
Publicado: (2017)

Impact of Diabetes Susceptibility Loci on Progression From Pre-Diabetes to Diabetes in At-Risk Individuals of the Diabetes Prevention Trial–Type 1 (DPT-1)
por: Butty, Vincent, et al.
Publicado: (2008)

Aire controls gene expression in the thymic epithelium with ordered stochasticity
por: Meredith, Matthew, et al.
Publicado: (2015)

The transcriptional regulator Aire binds to and activates super-enhancers
por: Bansal, Kushagra, et al.
Publicado: (2017)

Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
por: Littwitz-Salomon, Elisabeth, et al.
Publicado: (2015)

The effect of in vivo IL-7 deprivation on T cell maturation
Publicado: (1995)

Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells
por: Ojo, Evelyn O., et al.
Publicado: (2019)

IL-2–dependent adaptive control of NK cell homeostasis
por: Gasteiger, Georg, et al.
Publicado: (2013)

Sarcoma IL-12 overexpression facilitates NK cell immunomodulation
por: Rademacher, Mary Jo, et al.
Publicado: (2021)

Intratumor Regulatory Noncytotoxic NK Cells in Patients with Hepatocellular Carcinoma
por: Zecca, Alessandra, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_05c0ctctod4kgd5h9dm0034r8r