Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

Thymic involution during aging is a major cause of decreased production of T cells and reduced immunity. Here we show that inactivation of Rb family genes in young mice prevents thymic involution and results in an enlarged thymus competent for increased production of naive T cells. This phenotype or...

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Detalles Bibliográficos
Autores principales: Garfin, Phillip M., Min, Dullei, Bryson, Jerrod L., Serwold, Thomas, Edris, Badreddin, Blackburn, Clare C., Richie, Ellen R., Weinberg, Kenneth I., Manley, Nancy R., Sage, Julien, Viatour, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674705/
https://www.ncbi.nlm.nih.gov/pubmed/23669396
http://dx.doi.org/10.1084/jem.20121716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674705/
https://www.ncbi.nlm.nih.gov/pubmed/23669396
http://dx.doi.org/10.1084/jem.20121716

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