Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models

Heterozygous germline mutations and deletions in PHOX2B, a key regulator of autonomic neuron development, predispose to neuroblastoma, a tumor of the peripheral sympathetic nervous system. To gain insight into the oncogenic mechanisms engaged by these changes, we used zebrafish models to study the f...

Descripción completa

Detalles Bibliográficos
Autores principales: Pei, Desheng, Luther, William, Wang, Wenchao, Paw, Barry H., Stewart, Rodney A., George, Rani E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675015/
https://www.ncbi.nlm.nih.gov/pubmed/23754957
http://dx.doi.org/10.1371/journal.pgen.1003533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675015/
https://www.ncbi.nlm.nih.gov/pubmed/23754957
http://dx.doi.org/10.1371/journal.pgen.1003533

Ejemplares similares