Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4

Recently a novel inhibitor of Wnt signaling was discovered. The compound, WIKI4, was found to act through tankyrase inhibition and regulate β-catenin levels in many cancer cell lines and human embryonic stem cells. Here we confirm that WIKI4 is a high potency tankyrase inhibitor and that it selectiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Haikarainen, Teemu, Venkannagari, Harikanth, Narwal, Mohit, Obaji, Ezeogo, Lee, Hao-Wei, Nkizinkiko, Yves, Lehtiö, Lari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675114/
https://www.ncbi.nlm.nih.gov/pubmed/23762361
http://dx.doi.org/10.1371/journal.pone.0065404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675114/
https://www.ncbi.nlm.nih.gov/pubmed/23762361
http://dx.doi.org/10.1371/journal.pone.0065404

Ejemplares similares