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Transition between Acute and Chronic Hepatotoxicity in Mice Is Associated with Impaired Energy Metabolism and Induction of Mitochondrial Heme Oxygenase-1
The formation of protein inclusions is frequently associated with chronic metabolic diseases. In mice, short-term intoxication with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) leads to hepatocellular damage indicated by elevated serum liver enzyme activities, whereas only minor morphological cha...
Autores principales: | Nikam, Aniket, Patankar, Jay V., Lackner, Carolin, Schöck, Elisabeth, Kratky, Dagmar, Zatloukal, Kurt, Abuja, Peter M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675145/ https://www.ncbi.nlm.nih.gov/pubmed/23762471 http://dx.doi.org/10.1371/journal.pone.0066094 |
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