Chloroquine Promotes Apoptosis in Melanoma Cells by Inhibiting BH3 domain Mediated PUMA Degradation

The BH3-only protein PUMA counters Bcl-2 family anti-apoptotic proteins and promotes apoptosis. Although PUMA is a key regulator of apoptosis, the post-transcriptional mechanisms that control PUMA protein stability are not understood. We show that a lysosome-independent activity of chloroquine preve...

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Detalles Bibliográficos
Autores principales: Lakhter, Alexander J, Sahu, Ravi P, Sun, Yang, Kaufmann, William K, Androphy, Elliot J, Travers, Jeffrey B, Naidu, Samisubbu R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675185/
https://www.ncbi.nlm.nih.gov/pubmed/23370537
http://dx.doi.org/10.1038/jid.2013.56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675185/
https://www.ncbi.nlm.nih.gov/pubmed/23370537
http://dx.doi.org/10.1038/jid.2013.56

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