Cargando…

Chloroquine Promotes Apoptosis in Melanoma Cells by Inhibiting BH3 domain Mediated PUMA Degradation

The BH3-only protein PUMA counters Bcl-2 family anti-apoptotic proteins and promotes apoptosis. Although PUMA is a key regulator of apoptosis, the post-transcriptional mechanisms that control PUMA protein stability are not understood. We show that a lysosome-independent activity of chloroquine preve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lakhter, Alexander J, Sahu, Ravi P, Sun, Yang, Kaufmann, William K, Androphy, Elliot J, Travers, Jeffrey B, Naidu, Samisubbu R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675185/ https://www.ncbi.nlm.nih.gov/pubmed/23370537 http://dx.doi.org/10.1038/jid.2013.56

Ejemplares similares

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax
por: McKenzie, Mark D., et al.
Publicado: (2010)

PUMA: a puzzle piece in chloroquine’s antimelanoma activity
por: Amaravadi, Ravi K.
Publicado: (2013)

BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced Apoptosis
por: Roufayel, Rabih, et al.
Publicado: (2022)

The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells
por: Naidu, Samisubbu R., et al.
Publicado: (2009)

BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis
por: Holzerland, Julia, et al.
Publicado: (2020)

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
por: Shankar Babu, Mani, et al.
Publicado: (2018)

Cisplatin fails to induce puma mediated apoptosis in mucosal melanomas
por: Fritsche, Marie Kristin, et al.
Publicado: (2015)

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL
por: Delbridge, Alex RD, et al.
Publicado: (2017)

Mitochondrial apoptosis and BH3 mimetics
por: Dai, Haiming, et al.
Publicado: (2016)

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
por: Erlacher, Miriam, et al.
Publicado: (2006)

Gene expression during ER stress–induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway
por: Reimertz, Claus, et al.
Publicado: (2003)

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma
por: Lakhter, Alexander J., et al.
Publicado: (2014)

Role of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency
por: Ren, Decheng, et al.
Publicado: (2014)

Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk
por: Suraweera, Chathura D., et al.
Publicado: (2021)

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
por: Dai, Haiming, et al.
Publicado: (2011)

BH3 mimetics induce apoptosis independent of DRP-1 in melanoma
por: Mukherjee, Nabanita, et al.
Publicado: (2018)

Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells
por: Papaianni, Emanuela, et al.
Publicado: (2015)

BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β
por: Saha, Akash, et al.
Publicado: (2021)

BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus
por: Bunk, E C, et al.
Publicado: (2010)

Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members
por: Gallenne, Tristan, et al.
Publicado: (2009)

Correction: BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β
por: Saha, Akash, et al.
Publicado: (2021)

FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX
por: Manne, Rajesh Kumar, et al.
Publicado: (2021)

PUMA and Bax-induced Autophagy Contributes to Apoptosis
por: Yee, Karen S., et al.
Publicado: (2009)

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1
por: Jenson, Justin M, et al.
Publicado: (2017)

Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib
por: Florent, Romane, et al.
Publicado: (2020)

BH3 mimetics efficiently induce apoptosis in mouse basophils and mast cells
por: Reinhart, Ramona, et al.
Publicado: (2018)

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
por: Wali, J A, et al.
Publicado: (2014)

Chlamydia Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins
por: Fischer, Silke F., et al.
Publicado: (2004)

Puma (Puma concolor) epididymal sperm morphometry
por: Cucho, Hernán, et al.
Publicado: (2016)

Response of pumas (Puma concolor) to migration of their primary prey in Patagonia
por: Gelin, Maria L., et al.
Publicado: (2017)

PATZ1 Induces Apoptosis through PUMA in Glioblastoma
por: Tao, Xiang, et al.
Publicado: (2022)

Crystal Structures of Epstein–Barr Virus Bcl-2 Homolog BHRF1 Bound to Bid and Puma BH3 Motif Peptides
por: Suraweera, Chathura D., et al.
Publicado: (2022)

E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation
por: Hao, Hongying, et al.
Publicado: (2007)

PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy
por: Tan, S, et al.
Publicado: (2014)

The VTLISFG motif in the BH1 domain plays a significant role in regulating the degradation of Mcl-1()
por: Xiao, Kang, et al.
Publicado: (2014)

BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina
por: Harder, Jeffrey M, et al.
Publicado: (2011)

Interdependence of Bad and Puma during Ionizing-Radiation-Induced Apoptosis
por: Toruno, Cristhian, et al.
Publicado: (2014)

Idelalisib induces PUMA-dependent apoptosis in colon cancer cells
por: Yang, Shida, et al.
Publicado: (2016)

A case of Anthrax in two captive pumas (Puma concolor)
por: EKEBAS, Gorkem, et al.
Publicado: (2018)

Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer
por: Li, Haolong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_df3olgg93gvkha26n385t5vj67