Cargando…
Structure and mechanism of the 2′,3′ phosphatase component of the bacterial Pnkp-Hen1 RNA repair system
Pnkp is the end-healing and end-sealing component of an RNA repair system present in diverse bacteria from many phyla. Pnkp is composed of three catalytic modules: an N-terminal polynucleotide 5′ kinase, a central 2′,3′ phosphatase and a C-terminal ligase. The phosphatase module is a Mn(2+)-dependen...
Autores principales: | Wang, Li Kai, Smith, Paul, Shuman, Stewart |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675462/ https://www.ncbi.nlm.nih.gov/pubmed/23595150 http://dx.doi.org/10.1093/nar/gkt221 |
Ejemplares similares
-
Mechanism of RNA 2′,3′-cyclic phosphate end healing by T4 polynucleotide kinase–phosphatase
por: Das, Ushati, et al.
Publicado: (2013) -
Characterization of the 2′,3′ cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage λ phosphatase
por: Keppetipola, Niroshika, et al.
Publicado: (2007) -
Structure and two-metal mechanism of fungal tRNA ligase
por: Banerjee, Ankan, et al.
Publicado: (2019) -
Structural insights to the metal specificity of an archaeal member of the LigD 3′-phosphoesterase DNA repair enzyme family
por: Das, Ushati, et al.
Publicado: (2012) -
Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP•Mg(2+) and 5′-OH oligonucleotide and a product complex with GDP•Mg(2+) and 5′-PO(4) oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition
por: Das, Ushati, et al.
Publicado: (2014)