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Laser capture microdissection–reduced representation bisulfite sequencing (LCM-RRBS) maps changes in DNA methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse
DNA methylation is a mechanism for long-term transcriptional regulation and is required for normal cellular differentiation. Failure to properly establish or maintain DNA methylation patterns leads to cell dysfunction and diseases such as cancer. Identifying DNA methylation signatures in complex tis...
Autores principales: | Schillebeeckx, Maximiliaan, Schrade, Anja, Löbs, Ann-Kathrin, Pihlajoki, Marjut, Wilson, David B., Mitra, Robi D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675465/ https://www.ncbi.nlm.nih.gov/pubmed/23589626 http://dx.doi.org/10.1093/nar/gkt230 |
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