Thermodynamic studies of a series of homologous HIV-1 TAR RNA ligands reveal that loose binders are stronger Tat competitors than tight ones

RNA is a major drug target, but the design of small molecules that modulate RNA function remains a great challenge. In this context, a series of structurally homologous ‘polyamide amino acids’ (PAA) was studied as HIV-1 trans-activating response (TAR) RNA ligands. An extensive thermodynamic study re...

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Detalles Bibliográficos
Autores principales: Pascale, Lise, Azoulay, Stéphane, Di Giorgio, Audrey, Zenacker, Laura, Gaysinski, Marc, Clayette, Pascal, Patino, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675469/
https://www.ncbi.nlm.nih.gov/pubmed/23605042
http://dx.doi.org/10.1093/nar/gkt237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675469/
https://www.ncbi.nlm.nih.gov/pubmed/23605042
http://dx.doi.org/10.1093/nar/gkt237

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