RecJ-like protein from Pyrococcus furiosus has 3′–5′ exonuclease activity on RNA: implications for proofreading of 3′-mismatched RNA primers in DNA replication

Replicative DNA polymerases require an RNA primer for leading and lagging strand DNA synthesis, and primase is responsible for the de novo synthesis of this RNA primer. However, the archaeal primase from Pyrococcus furiosus (Pfu) frequently incorporates mismatched nucleoside monophosphate, which sto...

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Detalles Bibliográficos
Autores principales: Yuan, Hui, Liu, Xi-Peng, Han, Zhong, Allers, Thorsten, Hou, Jing-Li, Liu, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675489/
https://www.ncbi.nlm.nih.gov/pubmed/23605041
http://dx.doi.org/10.1093/nar/gkt275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675489/
https://www.ncbi.nlm.nih.gov/pubmed/23605041
http://dx.doi.org/10.1093/nar/gkt275

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