Thyroid Hormone Reverses Aging-Induced Myocardial Fatty Acid Oxidation Defects and Improves the Response to Acutely Increased Afterload

BACKGROUND: Subclinical hypothyroidism occurs during aging in humans and mice and may contribute to the development of heart failure. Aging also impairs myocardial fatty acid oxidation, causing increased reliance on flux through pyruvate dehydrogenase (PDH) to maintain function. We hypothesize that...

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Detalles Bibliográficos
Autores principales: Ledee, Dolena, Portman, Michael A., Kajimoto, Masaki, Isern, Nancy, Olson, Aaron K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676337/
https://www.ncbi.nlm.nih.gov/pubmed/23762386
http://dx.doi.org/10.1371/journal.pone.0065532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676337/
https://www.ncbi.nlm.nih.gov/pubmed/23762386
http://dx.doi.org/10.1371/journal.pone.0065532

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