3-Oxoacyl-ACP Reductase from Schistosoma japonicum: Integrated In Silico-In Vitro Strategy for Discovering Antischistosomal Lead Compounds

BACKGROUND: Schistosomiasis is a disease caused by parasitic worms and more than 200 million people are infected worldwide. The emergence of resistance to the most commonly used drug, praziquantel (PZQ), makes the development of novel drugs an urgent task. 3-oxoacyl-ACP reductase (OAR), a key enzyme...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Dyer, Dave, Wang, Jipeng, Wang, Shuqi, Du, Xiaofeng, Xu, Bin, Zhang, Haobing, Wang, Xiaoning, Hu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676400/
https://www.ncbi.nlm.nih.gov/pubmed/23762275
http://dx.doi.org/10.1371/journal.pone.0064984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676400/
https://www.ncbi.nlm.nih.gov/pubmed/23762275
http://dx.doi.org/10.1371/journal.pone.0064984

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