Substrate-specific structural rearrangements of human Dicer

Dicer plays a central role in RNA interference pathways by cleaving double-stranded RNAs (dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double-stranded and hairpin precursor RNAs to yield short interfering RNAs (siRNAs) or microRNAs (miRNAs), respectively. Previous studies h...

Descripción completa

Detalles Bibliográficos
Autores principales: Taylor, David W., Ma, Enbo, Shigematsu, Hideki, Cianfrocco, Michael A., Noland, Cameron L., Nagayama, Kuniaki, Nogales, Eva, Doudna, Jennifer A., Wang, Hong-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676429/
https://www.ncbi.nlm.nih.gov/pubmed/23624860
http://dx.doi.org/10.1038/nsmb.2564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676429/
https://www.ncbi.nlm.nih.gov/pubmed/23624860
http://dx.doi.org/10.1038/nsmb.2564

Ejemplares similares