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Substrate-specific structural rearrangements of human Dicer

Dicer plays a central role in RNA interference pathways by cleaving double-stranded RNAs (dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double-stranded and hairpin precursor RNAs to yield short interfering RNAs (siRNAs) or microRNAs (miRNAs), respectively. Previous studies h...

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Detalles Bibliográficos
Autores principales:	Taylor, David W., Ma, Enbo, Shigematsu, Hideki, Cianfrocco, Michael A., Noland, Cameron L., Nagayama, Kuniaki, Nogales, Eva, Doudna, Jennifer A., Wang, Hong-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676429/ https://www.ncbi.nlm.nih.gov/pubmed/23624860 http://dx.doi.org/10.1038/nsmb.2564

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