Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

Synaptic vesicle exocytosis is mediated by the vesicular Ca(2+)-sensor synaptotagmin-1. Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and with acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP2). However, it is unclear how these interactions contribute to trigger...

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Detalles Bibliográficos
Autores principales: Honigmann, Alf, van den Bogaart, Geert, Iraheta, Emilio, Risselada, H. Jelger, Milovanovic, Dragomir, Mueller, Veronika, Müllar, Stefan, Diederichsen, Ulf, Fasshauer, Dirk, Grubmüller, Helmut, Hell, Stefan W., Eggeling, Christian, Kühnel, Karin, Jahn, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676452/
https://www.ncbi.nlm.nih.gov/pubmed/23665582
http://dx.doi.org/10.1038/nsmb.2570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676452/
https://www.ncbi.nlm.nih.gov/pubmed/23665582
http://dx.doi.org/10.1038/nsmb.2570

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