Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity

IscR from Escherichia coli is an unusual metalloregulator in that it globally regulates transcription by recognizing two different DNA motifs in a Fe-S dependent manner. Here, we report structural and biochemical studies of IscR, which suggest remodeling of the protein-DNA interface upon Fe-S ligati...

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Detalles Bibliográficos
Autores principales: Rajagopalan, Senapathy, Teter, Sarah J., Zwart, Petrus H., Brennan, Richard G., Phillips, Kevin J., Kiley, Patricia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676455/
https://www.ncbi.nlm.nih.gov/pubmed/23644595
http://dx.doi.org/10.1038/nsmb.2568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676455/
https://www.ncbi.nlm.nih.gov/pubmed/23644595
http://dx.doi.org/10.1038/nsmb.2568

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