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Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity
IscR from Escherichia coli is an unusual metalloregulator in that it globally regulates transcription by recognizing two different DNA motifs in a Fe-S dependent manner. Here, we report structural and biochemical studies of IscR, which suggest remodeling of the protein-DNA interface upon Fe-S ligati...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676455/ https://www.ncbi.nlm.nih.gov/pubmed/23644595 http://dx.doi.org/10.1038/nsmb.2568 |