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Analysis of 6,515 exomes reveals a recent origin of most human protein-coding variants
Establishing the age of each mutation segregating in contemporary human populations is important to fully understand our evolutionary history(1,2) and will help facilitate the development of new approaches for disease gene discovery(3). Large-scale surveys of human genetic variation have reported si...
Autores principales: | Fu, Wenqing, O'Connor, Timothy D., Jun, Goo, Kang, Hyun Min, Abecasis, Goncalo, Leal, Suzanne M., Gabriel, Stacey, Altshuler, David, Shendure, Jay, Nickerson, Deborah A., Bamshad, Michael J., GO, Broad, GO, Seattle, Akey, Joshua M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676746/ https://www.ncbi.nlm.nih.gov/pubmed/23201682 http://dx.doi.org/10.1038/nature11690 |
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