Synthesis, Cytotoxicity, DNA Binding and Apoptosis of Rhein-Phosphonate Derivatives as Antitumor Agents

Several rhein-phosphonate derivatives (5a–c) were synthesized and evaluated for in vitro cytotoxicity against HepG-2, CNE, Spca-2, Hela and Hct-116 cell lines. Some compounds showed relatively high cytotoxicity. Especially compounds 5b exhibited the strongest cytotoxicity against HepG-2 and Spca-2 c...

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Detalles Bibliográficos
Autores principales: Ye, Man-Yi, Yao, Gui-Yang, Wei, Jing-Chen, Pan, Ying-Ming, Liao, Zhi-Xin, Wang, Heng-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676791/
https://www.ncbi.nlm.nih.gov/pubmed/23629673
http://dx.doi.org/10.3390/ijms14059424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676791/
https://www.ncbi.nlm.nih.gov/pubmed/23629673
http://dx.doi.org/10.3390/ijms14059424

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