Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. We present crystal structures of one representative member of each DYRK subfam...

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Detalles Bibliográficos
Autores principales: Soundararajan, Meera, Roos, Annette K., Savitsky, Pavel, Filippakopoulos, Panagis, Kettenbach, Arminja N., Olsen, Jesper V., Gerber, Scott A., Eswaran, Jeyanthy, Knapp, Stefan, Elkins, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677093/
https://www.ncbi.nlm.nih.gov/pubmed/23665168
http://dx.doi.org/10.1016/j.str.2013.03.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677093/
https://www.ncbi.nlm.nih.gov/pubmed/23665168
http://dx.doi.org/10.1016/j.str.2013.03.012

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