Cargando…

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. We present crystal structures of one representative member of each DYRK subfam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soundararajan, Meera, Roos, Annette K., Savitsky, Pavel, Filippakopoulos, Panagis, Kettenbach, Arminja N., Olsen, Jesper V., Gerber, Scott A., Eswaran, Jeyanthy, Knapp, Stefan, Elkins, Jonathan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677093/ https://www.ncbi.nlm.nih.gov/pubmed/23665168 http://dx.doi.org/10.1016/j.str.2013.03.012

Ejemplares similares

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases
por: Myrianthopoulos, Vassilios, et al.
Publicado: (2012)

Insights into protein kinase regulation and inhibition by large scale structural comparison
por: Eswaran, Jeyanthy, et al.
Publicado: (2010)

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs
por: Eswaran, Jeyanthy, et al.
Publicado: (2007)

Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics
por: Rusin, Scott F., et al.
Publicado: (2017)

SH2 domains: modulators of nonreceptor tyrosine kinase activity
por: Filippakopoulos, Panagis, et al.
Publicado: (2009)

Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis
por: Nasa, Isha, et al.
Publicado: (2018)

DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia
por: Szoltysek, Katarzyna, et al.
Publicado: (2020)

Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
por: Filippakopoulos, Panagis, et al.
Publicado: (2008)

A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase
por: Cullati, Sierra N., et al.
Publicado: (2017)

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site
por: Scheeff, Eric D., et al.
Publicado: (2009)

Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism
por: Peters, Daniel T., et al.
Publicado: (2018)

Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function
por: Kwiatkowski, Nicholas, et al.
Publicado: (2010)

Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A
por: Widowati, Esti Wahyu, et al.
Publicado: (2018)

Mirk/dyrk1B Kinase in Ovarian Cancer
por: Friedman, Eileen
Publicado: (2013)

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome
por: Ashford, Anne L., et al.
Publicado: (2015)

Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3
por: Schröder, Martin, et al.
Publicado: (2020)

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
por: Papenfuss, Marco, et al.
Publicado: (2022)

A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1
por: Opalko, Hannah E., et al.
Publicado: (2019)

Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control
por: Singh, Rajeev, et al.
Publicado: (2017)

The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities
por: Boni, Jacopo, et al.
Publicado: (2020)

Structural and Functional Characterization of the Human Protein Kinase ASK1
por: Bunkoczi, Gabor, et al.
Publicado: (2007)

Structure of the Human Protein Kinase MPSK1 Reveals an Atypical Activation Loop Architecture
por: Eswaran, Jeyanthy, et al.
Publicado: (2008)

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain
por: Abu Jhaisha, Samira, et al.
Publicado: (2017)

Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion
por: Orr, Amy, et al.
Publicado: (2015)

Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis
por: McNamara, Colleen R., et al.
Publicado: (2013)

Bromodomains as therapeutic targets
por: Muller, Susanne, et al.
Publicado: (2011)

Protein kinase DYRK2 is an E3-ligase specific molecular assembler
por: Maddika, Subbareddy, et al.
Publicado: (2009)

Mirk/dyrk1B kinase is upregulated following inhibition of mTOR
por: Deng, Xiaobing, et al.
Publicado: (2014)

Selective inhibition of the kinase DYRK1A by targeting its folding process
por: Kii, Isao, et al.
Publicado: (2016)

DYRK1A, a Novel Determinant of the Methionine-Homocysteine Cycle in Different Mouse Models Overexpressing this Down-Syndrome-Associated Kinase
por: Noll, Christophe, et al.
Publicado: (2009)

A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome–associated kinase Dyrk1A overexpression
por: Buchberger, Astrid, et al.
Publicado: (2021)

Inducible protein degradation as a strategy to identify Phosphoprotein Phosphatase 6 substrates in RAS-mutant colorectal cancer cells
por: Mariano, Natasha C., et al.
Publicado: (2023)

Inducible Protein Degradation as a Strategy to Identify Phosphoprotein Phosphatase 6 Substrates in RAS-Mutant Colorectal Cancer Cells
por: Mariano, Natasha C., et al.
Publicado: (2023)

Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview
por: Lindberg, Mattias F., et al.
Publicado: (2021)

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology
por: Ciceri, Pietro, et al.
Publicado: (2014)

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes†
por: Huber, Kilian, et al.
Publicado: (2011)

Roles of the DYRK Kinase Pom2 in Cytokinesis, Mitochondrial Morphology, and Sporulation in Fission Yeast
por: Wu, Pengcheng, et al.
Publicado: (2011)

The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer
por: Friedman, Eileen
Publicado: (2010)

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
por: Khor, Bernard, et al.
Publicado: (2015)

An ELISA DYRK1A non-radioactive kinase assay suitable for the characterization of inhibitors
por: Liu, Yong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_frkan02ggum23ol1h8kiv6m9u8