Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

The U5 small nuclear ribonucleoprotein particle (snRNP) helicase Brr2 disrupts the U4/U6 small nuclear RNA (snRNA) duplex and allows U6 snRNA to engage in an intricate RNA network at the active center of the spliceosome. Here, we present the structure of yeast Brr2 in complex with the Jab1/MPN domai...

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Detalles Bibliográficos
Autores principales: Nguyen, Thi Hoang Duong, Li, Jade, Galej, Wojciech P., Oshikane, Hiroyuki, Newman, Andrew J., Nagai, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677097/
https://www.ncbi.nlm.nih.gov/pubmed/23727230
http://dx.doi.org/10.1016/j.str.2013.04.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677097/
https://www.ncbi.nlm.nih.gov/pubmed/23727230
http://dx.doi.org/10.1016/j.str.2013.04.017

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