Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis

Npro is a key effector protein of pestiviruses such as bovine viral diarrhea virus and abolishes host cell antiviral defense mechanisms. Synthesized as the N-terminal part of the viral polyprotein, Npro releases itself via an autoproteolytic cleavage, triggering its immunological functions. However,...

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Detalles Bibliográficos
Autores principales: Zögg, Thomas, Sponring, Michael, Schindler, Sabrina, Koll, Maria, Schneider, Rainer, Brandstetter, Hans, Auer, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677099/
https://www.ncbi.nlm.nih.gov/pubmed/23643950
http://dx.doi.org/10.1016/j.str.2013.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677099/
https://www.ncbi.nlm.nih.gov/pubmed/23643950
http://dx.doi.org/10.1016/j.str.2013.04.003

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