Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia

LMO1 is a transcriptional regulator and a T-acute lymphoblastic leukaemia (T-ALL) oncogene. Although first identified in association with a chromosomal translocation in T-ALL, the ectopic expression of LMO1 occurs far more frequently in the absence of any known mutation involving its locus. Given th...

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Detalles Bibliográficos
Autores principales: Oram, S H, Thoms, J, Sive, J I, Calero-Nieto, F J, Kinston, S J, Schütte, J, Knezevic, K, Lock, R B, Pimanda, J E, Göttgens, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677138/
https://www.ncbi.nlm.nih.gov/pubmed/23302769
http://dx.doi.org/10.1038/leu.2013.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677138/
https://www.ncbi.nlm.nih.gov/pubmed/23302769
http://dx.doi.org/10.1038/leu.2013.2

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