Cargando…

Microtubule dynamic instability: A new model with coupled GTP hydrolysis and multistep catastrophe

A key question in understanding microtubule dynamics is how GTP hydrolysis leads to catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the experimental and modeling literature, and then present a new model of microtubule dynamics. We demonstrate that vectorial,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bowne-Anderson, Hugo, Zanic, Marija, Kauer, Monika, Howard, Jonathon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2013
Materias:	Prospects & Overviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677417/ https://www.ncbi.nlm.nih.gov/pubmed/23532586 http://dx.doi.org/10.1002/bies.201200131

Ejemplares similares

Beyond the GTP-cap: Elucidating the molecular mechanisms of microtubule catastrophe
por: Farmer, Veronica J., et al.
Publicado: (2023)

P53 and the defenses against genome instability caused by transposons and repetitive elements
por: Levine, Arnold J., et al.
Publicado: (2016)

Islands Containing Slowly Hydrolyzable GTP Analogs Promote Microtubule Rescues
por: Tropini, Carolina, et al.
Publicado: (2012)

Mitochondria and the culture of the Borg
por: Braschi, Emelie, et al.
Publicado: (2010)

Orthology prediction methods: A quality assessment using curated protein families
por: Trachana, Kalliopi, et al.
Publicado: (2011)

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models
por: Huijbers, Ivo J, et al.
Publicado: (2011)

Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?
por: Kell, Douglas B
Publicado: (2012)

Long non-coding RNA modifies chromatin: Epigenetic silencing by long non-coding RNAs
por: Saxena, Alka, et al.
Publicado: (2011)

From transporter to transceptor: Signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls: Endocytic internalization and intracellular trafficking of nutrient transceptors may, at least in part, be governed by their signaling function
por: Kriel, Johan, et al.
Publicado: (2011)

Function and evolution of sex determination mechanisms, genes and pathways in insects
por: Gempe, Tanja, et al.
Publicado: (2011)

Upstream open reading frames: Molecular switches in (patho)physiology
por: Wethmar, Klaus, et al.
Publicado: (2010)

Innovation in biological microscopy: Current status and future directions
por: Swedlow, Jason R
Publicado: (2012)

Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges
por: Deelen, Joris, et al.
Publicado: (2013)

Population transcriptomics with single-cell resolution: A new field made possible by microfluidics: A technology for high throughput transcript counting and data-driven definition of cell types
por: Plessy, Charles, et al.
Publicado: (2013)

Current status of drug screening and disease modelling in human pluripotent stem cells
por: Rajamohan, Divya, et al.
Publicado: (2013)

The emerging biology of muscle stem cells: Implications for cell-based therapies
por: Bentzinger, C Florian, et al.
Publicado: (2013)

Circadian rhythms and mood: Opportunities for multi-level analyses in genomics and neuroscience
por: Li, Jun Z
Publicado: (2014)

Transfer and functional consequences of dietary microRNAs in vertebrates: Concepts in search of corroboration: Negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist
por: Witwer, Kenneth W, et al.
Publicado: (2014)

Variable escape from X-chromosome inactivation: Identifying factors that tip the scales towards expression
por: Peeters, Samantha B, et al.
Publicado: (2014)

Keeping your armour intact: How HIV-1 evades detection by the innate immune system
por: Maelfait, Jonathan, et al.
Publicado: (2014)

Pausing for thought: Disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis
por: Jennings, Barbara H
Publicado: (2013)

Multi-step down-regulation of the secretory pathway in mitosis: A fresh perspective on protein trafficking
por: Yeong, Foong May
Publicado: (2013)

Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?
por: Nora, Elphège P, et al.
Publicado: (2013)

Stress-induced mutation via DNA breaks in Escherichia coli: A molecular mechanism with implications for evolution and medicine
por: Rosenberg, Susan M, et al.
Publicado: (2012)

A frontier in the understanding of synaptic plasticity: Solving the structure of the postsynaptic density
por: Gold, Matthew G
Publicado: (2012)

Transcriptional mechanisms of cell fate decisions revealed by single cell expression profiling
por: Moignard, Victoria, et al.
Publicado: (2014)

Functional interpretation of non-coding sequence variation: Concepts and challenges
por: Paul, Dirk S, et al.
Publicado: (2014)

Modeling and simulation of biological systems from image data
por: Sbalzarini, Ivo F
Publicado: (2013)

Sources of dynamic variability in NF-κB signal transduction: A mechanistic model
por: Mothes, Janina, et al.
Publicado: (2015)

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification
por: Iyer, Lakshminarayan M., et al.
Publicado: (2015)

Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function
por: Dueck, Hannah, et al.
Publicado: (2015)

Mouse models of colorectal cancer as preclinical models
por: McIntyre, Rebecca E., et al.
Publicado: (2015)

Fetal microchimerism and maternal health: A review and evolutionary analysis of cooperation and conflict beyond the womb
por: Boddy, Amy M., et al.
Publicado: (2015)

Luminescent sensing and imaging of oxygen: Fierce competition to the Clark electrode
por: Wolfbeis, Otto S.
Publicado: (2015)

Introns and gene expression: Cellular constraints, transcriptional regulation, and evolutionary consequences
por: Heyn, Patricia, et al.
Publicado: (2015)

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research
por: Hoitzing, Hanne, et al.
Publicado: (2015)

Shaping mitotic chromosomes: From classical concepts to molecular mechanisms
por: Kschonsak, Marc, et al.
Publicado: (2015)

Wax, sex and the origin of species: Dual roles of insect cuticular hydrocarbons in adaptation and mating
por: Chung, Henry, et al.
Publicado: (2015)

A meiotic mystery: How sister kinetochores avoid being pulled in opposite directions during the first division
por: Nasmyth, Kim
Publicado: (2015)

Bacterial cooperation in the wild and in the clinic: Are pathogen social behaviours relevant outside the laboratory?
por: Harrison, Freya
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5trria97rapm5sr10avmh1kc0f